' 
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Top Medical Research Studies
9.5
High homocysteine management strategy
Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events.
Vitamins show potential benefits
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Read More
8
Vitamin B6 supports blood clot treatment
[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
Moderately relevant vitamin B6 findings
We explored the effectiveness of vitamin B6 in treating patients suffering from pulmonary thromboembolism linked to deficiencies in protein C (PC) and protein S (PS). In our analysis of two male patients, we found that they presented with common symptoms such as lower limb pain, chest pain, and even decreased vision.
Using color Doppler flow imaging, we identified lower deep venous thrombosis in both cases, while multislice CT angiography revealed pulmonary embolism. Interestingly, both patients had decreased levels of plasma PC and PS alongside elevated homocysteine levels. After recognizing their deficiencies, we introduced vitamin B6 along with anticoagulant therapy to manage their symptoms.
The incorporation of vitamin B6 appeared to significantly improve the patients’ conditions, indicating a potentially beneficial role in such cases. It highlights the importance of considering congenital thrombophilia and its treatment options for young patients experiencing recurrent blood clots without clear causes. Overall, vitamin B6 might enhance treatment outcomes in managing blood clots associated with these specific deficiencies.
Using color Doppler flow imaging, we identified lower deep venous thrombosis in both cases, while multislice CT angiography revealed pulmonary embolism. Interestingly, both patients had decreased levels of plasma PC and PS alongside elevated homocysteine levels. After recognizing their deficiencies, we introduced vitamin B6 along with anticoagulant therapy to manage their symptoms.
The incorporation of vitamin B6 appeared to significantly improve the patients’ conditions, indicating a potentially beneficial role in such cases. It highlights the importance of considering congenital thrombophilia and its treatment options for young patients experiencing recurrent blood clots without clear causes. Overall, vitamin B6 might enhance treatment outcomes in managing blood clots associated with these specific deficiencies.
Read More
9
Homocystinuria treatment with B6
Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient.
Significant, vitamin B6's role noted
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
Read More
Most Useful Reviews
8.8
Less clots now
I take B6 to increase progesterone. My periods had been beyond heavy, accompanied by large blood clots, common symptoms of low progesterone. After taking Solgar’s B6 twice daily for six weeks, I've noticed improvements. I ovulated, had no spotting, and my period came on time, much lighter with fewer clots. It's still early days, but I feel in control now.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
9.5
High homocysteine management strategy
Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events.
Vitamins show potential benefits
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Read More
9
Vitamin B6 in CVST treatment
Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification.
Study limits isolated B6 effects
We explored the connection between vitamin levels and cerebral venous sinus thrombosis (CVST), particularly focusing on vitamin B6. Our case series documented three instances of CVST where patients presented with headaches, and two experienced additional symptoms like visual disturbances.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
Read More
9
Homocystinuria treatment with B6
Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient.
Significant, vitamin B6's role noted
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
Read More
8
Vitamin B6 may reduce blood clots
Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: A randomized field trial.
Significant but limited relevance.
We looked into the effects of Vitamin B6, along with B12 and folic acid, on the risk of blood clots among Indian soldiers stationed at high altitudes. This study aimed to find out if these vitamins could lower homocysteine levels—an amino acid linked to an increased risk of thrombosis.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
Read More
8
Case report on vitamin B6
Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis.
Limited insight on vitamin B6
We explored a fascinating case involving a young woman who faced severe, recurring thrombotic events linked to exceptionally high levels of homocysteine in her blood—an amino acid known to be harmful to blood vessels. In her treatment, doctors combined anticoagulation therapy with warfarin and vitamin supplementation, including vitamin B6, vitamin B12, and folate.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Less clots now
I take B6 to increase progesterone. My periods had been beyond heavy, accompanied by large blood clots, common symptoms of low progesterone. After taking Solgar’s B6 twice daily for six weeks, I've noticed improvements. I ovulated, had no spotting, and my period came on time, much lighter with fewer clots. It's still early days, but I feel in control now.
Read More
